The hepatoprotective effect of alcoholic extract of Annona squamosa leaves on experimentally induced liver injury in swiss albino mice

Annona squamosa is a multipurpose tree with edible fruits and is a source of medicinal and industrial products. The alkaloids present in Annona squamosa, a medicinal plant has proved to have antioxidant activity. The present study has been designed to evaluate the hepatoprotective effect of custard apple (Annona squamosa) in Diethylnitrosamine (DEN) induced swiss albino mice. Analysis of selected biochemical parameters (Total protein, Glutamyl Oxaloacetate Transaminase (GOT), Glutamyl Pyruvate Transaminase (GPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Alpha Fetoprotein (AFP), Total and Direct bilirubin) in serum and tissue and also histopathological studies in liver are carried out in control and experimental mice. The levels of GOT, GPT, ALP, Total and Direct Bilirubin (both in serum and tissue), ACP, AFP (only in serum) are increased, and it is decreased in DEN induced along with Annona squamosa extract groups. But total proteins are found to decrease in DEN induced mice and increase in DEN induced along with Annona squamosa extract groups. Histopathology also confirms the hepato protective effect of Annona squamosa. So, our study has been recommended the herbal treatment of hepatoprotective effect using this plant for effective remedial. Further characterization and purification of the individual component in this plant is also suggested in formulating the strategy of treatment.